Clinical characteristics, evolution, and treatment-related risk factors for mortality among immunosuppressed patients with influenza A (H1N1) virus admitted to the intensive care unit.
Identifieur interne : 000076 ( Main/Exploration ); précédent : 000075; suivant : 000077Clinical characteristics, evolution, and treatment-related risk factors for mortality among immunosuppressed patients with influenza A (H1N1) virus admitted to the intensive care unit.
Auteurs : José Garnacho-Montero [Espagne] ; Cristina Le N-Moya [Espagne] ; Antonio Gutiérrez-Pizarraya [Espagne] ; Angel Arenzana-Seisdedos [Espagne] ; Loreto Vidaur [Espagne] ; José Eugenio Guerrero [Espagne] ; M Nica Gord N [Espagne] ; Ignacio Martín-Loeches [Irlande (pays)] ; Alejandro Rodriguez [Espagne]Source :
- Journal of critical care [ 1557-8615 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Enregistrements (MeSH), Espagne (MeSH), Facteurs de risque (MeSH), Femelle (MeSH), Grippe humaine (mortalité), Hospitalisation (MeSH), Humains (MeSH), Modèles logistiques (MeSH), Mâle (MeSH), Scores de dysfonction d'organes (MeSH), Sous-type H1N1 du virus de la grippe A (MeSH), Sujet immunodéprimé (MeSH), Sujet âgé (MeSH), Unités de soins intensifs (MeSH), Études de cohortes (MeSH), Études prospectives (MeSH).
- MESH :
- mortalité : Grippe humaine.
- Adulte, Adulte d'âge moyen, Enregistrements, Espagne, Facteurs de risque, Femelle, Hospitalisation, Humains, Modèles logistiques, Mâle, Scores de dysfonction d'organes, Sous-type H1N1 du virus de la grippe A, Sujet immunodéprimé, Sujet âgé, Unités de soins intensifs, Études de cohortes, Études prospectives.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Cohort Studies (MeSH), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Immunocompromised Host (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (mortality), Intensive Care Units (MeSH), Logistic Models (MeSH), Male (MeSH), Middle Aged (MeSH), Organ Dysfunction Scores (MeSH), Prospective Studies (MeSH), Registries (MeSH), Risk Factors (MeSH), Spain (MeSH).
- MESH :
- geographic : Spain.
- mortality : Influenza, Human.
- Adult, Aged, Cohort Studies, Female, Hospitalization, Humans, Immunocompromised Host, Influenza A Virus, H1N1 Subtype, Intensive Care Units, Logistic Models, Male, Middle Aged, Organ Dysfunction Scores, Prospective Studies, Registries, Risk Factors.
Abstract
PURPOSE
Information about immunocompromised patients infected with influenza A (H1N1) virus and requiring admission to the ICU is lacking. Our objective was to know the clinical characteristics of these patients and to identify treatment-related variables associated with mortality.
MATERIAL AND METHODS
A prospective multicenter observational cohort study was based on data from a Spanish registry (2009-2015) collected by 148 Spanish ICUs. All patients admitted to the ICU with the diagnosis of influenza A (H1N1) virus infection were included. Immunosuppression was clearly defined. Factors associated with mortality in immunocompromised patients were assessed by conventional logistic regression analysis and by a propensity score (PS) adjusted-multivariable analysis.
RESULTS
Of 1899 patients with influenza A (H1N1) infection, 238 (12.5%) were classified as immunocompromised. Mortality was significantly higher in immunosuppressed patients. Four variables independently associated with mortality were identified: SOFA score, need of vasopressor, use of corticosteroids, and acute renal failure, AKIN 3 stage. In the PS-adjusted model, corticosteroid therapy remained as an independent factor associated with increased mortality (OR 2.25;95%CI, 1.15-4.38;p = 0.017). In the subgroup of hematological patients (n = 141), corticosteroid therapy was also associated with increased mortality (OR 3.12; 95%CI, 1.32-7.41; p = 0.010).
CONCLUSION
Immunocompromised individuals with influenza A (H1N1) admitted to the ICU have a poor outcome. In this population, the use of corticosteroids is strongly discouraged.
DOI: 10.1016/j.jcrc.2018.08.017
PubMed: 30216935
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<author><name sortKey="Martin Loeches, Ignacio" sort="Martin Loeches, Ignacio" uniqKey="Martin Loeches I" first="Ignacio" last="Martín-Loeches">Ignacio Martín-Loeches</name>
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<author><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodriguez">Alejandro Rodriguez</name>
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<author><name sortKey="Le N Moya, Cristina" sort="Le N Moya, Cristina" uniqKey="Le N Moya C" first="Cristina" last="Le N-Moya">Cristina Le N-Moya</name>
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<author><name sortKey="Gutierrez Pizarraya, Antonio" sort="Gutierrez Pizarraya, Antonio" uniqKey="Gutierrez Pizarraya A" first="Antonio" last="Gutiérrez-Pizarraya">Antonio Gutiérrez-Pizarraya</name>
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<author><name sortKey="Arenzana Seisdedos, Angel" sort="Arenzana Seisdedos, Angel" uniqKey="Arenzana Seisdedos A" first="Angel" last="Arenzana-Seisdedos">Angel Arenzana-Seisdedos</name>
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<author><name sortKey="Vidaur, Loreto" sort="Vidaur, Loreto" uniqKey="Vidaur L" first="Loreto" last="Vidaur">Loreto Vidaur</name>
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<wicri:regionArea>Intensive Care Unit, Hospital Donostia, San Sebastian</wicri:regionArea>
<wicri:noRegion>San Sebastian</wicri:noRegion>
</affiliation>
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<author><name sortKey="Guerrero, Jose Eugenio" sort="Guerrero, Jose Eugenio" uniqKey="Guerrero J" first="José Eugenio" last="Guerrero">José Eugenio Guerrero</name>
<affiliation wicri:level="3"><nlm:affiliation>Intensive Care Unit, Hospital Gregorio Marañón, Madrid, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Intensive Care Unit, Hospital Gregorio Marañón, Madrid</wicri:regionArea>
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</placeName>
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<author><name sortKey="Gord N, M Nica" sort="Gord N, M Nica" uniqKey="Gord N M" first="M Nica" last="Gord N">M Nica Gord N</name>
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<country xml:lang="fr">Espagne</country>
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<wicri:noRegion>Hospital La Fe. Valencia</wicri:noRegion>
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<author><name sortKey="Martin Loeches, Ignacio" sort="Martin Loeches, Ignacio" uniqKey="Martin Loeches I" first="Ignacio" last="Martín-Loeches">Ignacio Martín-Loeches</name>
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<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Anesthesia and Critical Care, St James ́s University Hospital, Trinity Centre for Health Sciences, Multidisciplinary Intensive Care Research Organization (MICRO), Dublin</wicri:regionArea>
<wicri:noRegion>Dublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodriguez">Alejandro Rodriguez</name>
<affiliation wicri:level="1"><nlm:affiliation>Critical Care Department URV/IISPV/CIBERES, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Critical Care Department URV/IISPV/CIBERES, Hospital Universitari de Tarragona Joan XXIII, Tarragona</wicri:regionArea>
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<series><title level="j">Journal of critical care</title>
<idno type="eISSN">1557-8615</idno>
<imprint><date when="2018" type="published">2018</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Cohort Studies (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hospitalization (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immunocompromised Host (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (MeSH)</term>
<term>Influenza, Human (mortality)</term>
<term>Intensive Care Units (MeSH)</term>
<term>Logistic Models (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Organ Dysfunction Scores (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Registries (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Spain (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Enregistrements (MeSH)</term>
<term>Espagne (MeSH)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (mortalité)</term>
<term>Hospitalisation (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Modèles logistiques (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Scores de dysfonction d'organes (MeSH)</term>
<term>Sous-type H1N1 du virus de la grippe A (MeSH)</term>
<term>Sujet immunodéprimé (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Unités de soins intensifs (MeSH)</term>
<term>Études de cohortes (MeSH)</term>
<term>Études prospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Immunocompromised Host</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Intensive Care Units</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Organ Dysfunction Scores</term>
<term>Prospective Studies</term>
<term>Registries</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enregistrements</term>
<term>Espagne</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Scores de dysfonction d'organes</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sujet immunodéprimé</term>
<term>Sujet âgé</term>
<term>Unités de soins intensifs</term>
<term>Études de cohortes</term>
<term>Études prospectives</term>
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<front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b>
</p>
<p>Information about immunocompromised patients infected with influenza A (H1N1) virus and requiring admission to the ICU is lacking. Our objective was to know the clinical characteristics of these patients and to identify treatment-related variables associated with mortality.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>MATERIAL AND METHODS</b>
</p>
<p>A prospective multicenter observational cohort study was based on data from a Spanish registry (2009-2015) collected by 148 Spanish ICUs. All patients admitted to the ICU with the diagnosis of influenza A (H1N1) virus infection were included. Immunosuppression was clearly defined. Factors associated with mortality in immunocompromised patients were assessed by conventional logistic regression analysis and by a propensity score (PS) adjusted-multivariable analysis.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Of 1899 patients with influenza A (H1N1) infection, 238 (12.5%) were classified as immunocompromised. Mortality was significantly higher in immunosuppressed patients. Four variables independently associated with mortality were identified: SOFA score, need of vasopressor, use of corticosteroids, and acute renal failure, AKIN 3 stage. In the PS-adjusted model, corticosteroid therapy remained as an independent factor associated with increased mortality (OR 2.25;95%CI, 1.15-4.38;p = 0.017). In the subgroup of hematological patients (n = 141), corticosteroid therapy was also associated with increased mortality (OR 3.12; 95%CI, 1.32-7.41; p = 0.010).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Immunocompromised individuals with influenza A (H1N1) admitted to the ICU have a poor outcome. In this population, the use of corticosteroids is strongly discouraged.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2019</Year>
<Month>10</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>10</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-8615</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>48</Volume>
<PubDate><Year>2018</Year>
<Month>12</Month>
</PubDate>
</JournalIssue>
<Title>Journal of critical care</Title>
<ISOAbbreviation>J Crit Care</ISOAbbreviation>
</Journal>
<ArticleTitle>Clinical characteristics, evolution, and treatment-related risk factors for mortality among immunosuppressed patients with influenza A (H1N1) virus admitted to the intensive care unit.</ArticleTitle>
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<Abstract><AbstractText Label="PURPOSE">Information about immunocompromised patients infected with influenza A (H1N1) virus and requiring admission to the ICU is lacking. Our objective was to know the clinical characteristics of these patients and to identify treatment-related variables associated with mortality.</AbstractText>
<AbstractText Label="MATERIAL AND METHODS">A prospective multicenter observational cohort study was based on data from a Spanish registry (2009-2015) collected by 148 Spanish ICUs. All patients admitted to the ICU with the diagnosis of influenza A (H1N1) virus infection were included. Immunosuppression was clearly defined. Factors associated with mortality in immunocompromised patients were assessed by conventional logistic regression analysis and by a propensity score (PS) adjusted-multivariable analysis.</AbstractText>
<AbstractText Label="RESULTS">Of 1899 patients with influenza A (H1N1) infection, 238 (12.5%) were classified as immunocompromised. Mortality was significantly higher in immunosuppressed patients. Four variables independently associated with mortality were identified: SOFA score, need of vasopressor, use of corticosteroids, and acute renal failure, AKIN 3 stage. In the PS-adjusted model, corticosteroid therapy remained as an independent factor associated with increased mortality (OR 2.25;95%CI, 1.15-4.38;p = 0.017). In the subgroup of hematological patients (n = 141), corticosteroid therapy was also associated with increased mortality (OR 3.12; 95%CI, 1.32-7.41; p = 0.010).</AbstractText>
<AbstractText Label="CONCLUSION">Immunocompromised individuals with influenza A (H1N1) admitted to the ICU have a poor outcome. In this population, the use of corticosteroids is strongly discouraged.</AbstractText>
<CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Garnacho-Montero</LastName>
<ForeName>José</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Intensive Care Clinical Unit, Hospital Universitario Virgen Macarena, Seville, Spain; Instituto de Biomedicina. Sevilla (IBIS), Seville, Spain. Electronic address: jgarnachom@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>León-Moya</LastName>
<ForeName>Cristina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Critical Care and Emergency Unit. H. San Juan de Dios del Aljarafe, Bormujos, Seville, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gutiérrez-Pizarraya</LastName>
<ForeName>Antonio</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Intensive Care Clinical Unit, Hospital Universitario Virgen Macarena, Seville, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arenzana-Seisdedos</LastName>
<ForeName>Angel</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Intensive Care Clinical Unit, Hospital Universitario Virgen Macarena, Seville, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Vidaur</LastName>
<ForeName>Loreto</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Hospital Donostia, San Sebastian, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guerrero</LastName>
<ForeName>José Eugenio</ForeName>
<Initials>JE</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Hospital Gregorio Marañón, Madrid, Spain.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Gordón</LastName>
<ForeName>Mónica</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Intensive Care Unit, Hospital La Fe. Valencia, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Martín-Loeches</LastName>
<ForeName>Ignacio</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesia and Critical Care, St James ́s University Hospital, Trinity Centre for Health Sciences, Multidisciplinary Intensive Care Research Organization (MICRO), Dublin, Ireland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rodriguez</LastName>
<ForeName>Alejandro</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Critical Care Department URV/IISPV/CIBERES, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>on Behalf GETGAG Study Group</CollectiveName>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
<PublicationType UI="D064888">Observational Study</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>08</Month>
<Day>24</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Crit Care</MedlineTA>
<NlmUniqueID>8610642</NlmUniqueID>
<ISSNLinking>0883-9441</ISSNLinking>
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<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="Y">Influenza A Virus, H1N1 Subtype</DescriptorName>
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<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
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<MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName>
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<MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D063305" MajorTopicYN="N">Organ Dysfunction Scores</DescriptorName>
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<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
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<MeshHeading><DescriptorName UI="D012042" MajorTopicYN="N">Registries</DescriptorName>
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<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
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<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>04</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>07</Month>
<Day>02</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>08</Month>
<Day>17</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>9</Month>
<Day>15</Day>
<Hour>6</Hour>
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<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>10</Month>
<Day>16</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>9</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30216935</ArticleId>
<ArticleId IdType="pii">S0883-9441(18)30457-X</ArticleId>
<ArticleId IdType="doi">10.1016/j.jcrc.2018.08.017</ArticleId>
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<affiliations><list><country><li>Espagne</li>
<li>Irlande (pays)</li>
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<region><li>Communauté de Madrid</li>
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<settlement><li>Madrid</li>
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<tree><country name="Espagne"><noRegion><name sortKey="Garnacho Montero, Jose" sort="Garnacho Montero, Jose" uniqKey="Garnacho Montero J" first="José" last="Garnacho-Montero">José Garnacho-Montero</name>
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<name sortKey="Gord N, M Nica" sort="Gord N, M Nica" uniqKey="Gord N M" first="M Nica" last="Gord N">M Nica Gord N</name>
<name sortKey="Guerrero, Jose Eugenio" sort="Guerrero, Jose Eugenio" uniqKey="Guerrero J" first="José Eugenio" last="Guerrero">José Eugenio Guerrero</name>
<name sortKey="Gutierrez Pizarraya, Antonio" sort="Gutierrez Pizarraya, Antonio" uniqKey="Gutierrez Pizarraya A" first="Antonio" last="Gutiérrez-Pizarraya">Antonio Gutiérrez-Pizarraya</name>
<name sortKey="Le N Moya, Cristina" sort="Le N Moya, Cristina" uniqKey="Le N Moya C" first="Cristina" last="Le N-Moya">Cristina Le N-Moya</name>
<name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodriguez">Alejandro Rodriguez</name>
<name sortKey="Vidaur, Loreto" sort="Vidaur, Loreto" uniqKey="Vidaur L" first="Loreto" last="Vidaur">Loreto Vidaur</name>
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<country name="Irlande (pays)"><noRegion><name sortKey="Martin Loeches, Ignacio" sort="Martin Loeches, Ignacio" uniqKey="Martin Loeches I" first="Ignacio" last="Martín-Loeches">Ignacio Martín-Loeches</name>
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